Lacidipine: Beyond Hypertension-Cardiovascular, Neuroprotective, and Renoprotective Effects
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Date
2026-01-29
Authors
Soumarshi Das
Prabir Maity
Anjali Sharma
Sarita Jangra
Journal Title
Journal ISSN
Volume Title
Publisher
Chitkara University Publications
Abstract
Background: Hypertension remains a leading contributor to cardiovascular, cerebrovascular, and renal disease worldwide. While calcium channel blockers are well established for blood pressure management, growing attention is being given to agents that provide organ protection beyond hemodynamic control. Lacidipine, a highly lipophilic dihydropyridine calcium channel blocker, shows strong membrane affinity and antioxidant properties, suggesting potential benefits that extend beyond its antihypertensive role.
Purpose: This review critically examines lacidipine’s therapeutic profile by integrating evidence of its vascular, cardiovascular, neurovascular, and renal protective effects alongside its established clinical use.
Methods: A comprehensive analysis of preclinical studies, clinical trials, and mechanistic reports was conducted to examine lacidipine’s pharmacological properties, antioxidant activity, and vasoprotective roles beyond blood pressure control.
Results: Lacidipine exhibits pronounced vascular selectivity and sustained activity with good tolerability in clinical use. Experimental studies demonstrate antioxidant and anti-inflammatory effects that mitigate endothelial dysfunction, vascular remodeling, and oxidative injury. Clinical evidence supports its efficacy is comparable to other major antihypertensive classes. Emerging data further indicate neuroprotective effects in models of stroke and neurodegeneration, renoprotective actions through improved microvascular and glomerular function, and cardioprotective benefits including attenuation of left ventricular hypertrophy and atherosclerotic progression.
Conclusions: Beyond effective blood pressure management, lacidipine shows multi organ protective properties that may enhance long term outcomes in hypertension associated disorders. Further studies are warranted to validate these benefits in clinical settings and to explore repositioning strategies that leverage its pleiotropic therapeutic potential.
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Keywords
Lacidipine, Calcium antagonist, Hypertension, Atherosclerosis, Neuroprotection, Cardiovascular disease