Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/2745
Title: DEVELOPMENT AND CHARACTERIZATION OF SOLID DISPERSIONS AND MICROSPHERES FOR SOLUBILITY ENHANCEMENT OF BCS CLASS II DRUG: COMPARATIVE STUDY
Authors: Kanojia, Neha
Keywords: SOLID DISPERSIONS
MICROSPHERES
BCS CLASS II DRUG
Issue Date: 28-Jul-2021
Publisher: Chitkara University Publications
Abstract: Hypercholesterolemia, and hence atherosclerosis, has been the major cause of cardiovascular mortality and morbidity. Across the globe, it is responsible for almost twice and ten times as many deaths as caused by cancer and accidents, respectively. The coronary heart disease (CHD) can be associated with high serum cholesterol levels that contribute to atherosclerosis. A significant reduction in serum cholesterol levels lowers the risk of CHD. Statins reduces the low-density lipoprotein (LDL) cholesterol levels by inhibition of 3-hydroxy-3-methylglutaryl-CoA (HMG- CoA) reductase enzyme. Fluvastatin sodium (FLS) is hypolipidemic drug which belongs to BCS class II having log P (4.17) and low water solubility (0.0039 mg/mL) which causes lesser drug dissolution and therefore, poor oral bioavailability. Various solubility improvement techniques includes use of co-solvents, microspheres, inclusion complexes, liquisolid compact, size reduction and solid dispersion technology.
URI: http://hdl.handle.net/123456789/2745
Appears in Collections:Doctoral Theses

Files in This Item:
File Description SizeFormat 
Title Page.pdf9.26 kBAdobe PDFView/Open
1. Introduction.pdf578.11 kBAdobe PDFView/Open
2. Literature Review.pdf103.75 kBAdobe PDFView/Open
3. Methodology.pdf856.8 kBAdobe PDFView/Open
4. Results & Discussion.pdf3.69 MBAdobe PDFView/Open
5. Summary and conclusion.pdf457.34 kBAdobe PDFView/Open
006 References.pdf606.23 kBAdobe PDFView/Open
80_Recommendation.pdf51.74 kBAdobe PDFView/Open
ABSTRACT.pdf47.23 kBAdobe PDFView/Open
CERTIFICATES.pdf17.13 kBAdobe PDFView/Open
PRELIMINARY PAGES.pdf126.01 kBAdobe PDFView/Open
PRELIMINARY PAGES.pdf126.01 kBAdobe PDFView/Open


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