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Title: Application of Central Composite Design for Development and Optimization of Eflornithine Hydrochloride-loaded Sustained Release Solid Lipid Microparticles
Authors: Ikmeet Kaur Grewal
Sukhbir Singh
Sandeep Arora
Neelam Sharma
Keywords: Apparent permeability coefficient
central composite design
eflornithine hydrochloride
Issue Date: 2022
Publisher: Biointerface research in Applied Chemistry
Abstract: Topical application of eflornithine hydrochloride (EFH) is the only available non-hormonal and non-systemic choice available for hirsutism treatment. EFH has low permeability (log P is -2.9). The current investigation's objective is the development of solid lipid microparticles-based sustained topical release delivery with enhanced permeability of eflornithine hydrochloride. EFH-loaded solid lipid microparticles (EFH-SLM) composed of Monecol PC and Softemul 165 using emulsion solvent evaporation technique.
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