Application of Central Composite Design for Development and Optimization of Eflornithine Hydrochloride-loaded Sustained Release Solid Lipid Microparticles

Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/2638

Title:	Application of Central Composite Design for Development and Optimization of Eflornithine Hydrochloride-loaded Sustained Release Solid Lipid Microparticles
Authors:	Ikmeet Kaur Grewal Sukhbir Singh Sandeep Arora Neelam Sharma
Keywords:	Apparent permeability coefficient central composite design eflornithine hydrochloride
Issue Date:	2022
Publisher:	Biointerface research in Applied Chemistry
Abstract:	Topical application of eflornithine hydrochloride (EFH) is the only available non-hormonal and non-systemic choice available for hirsutism treatment. EFH has low permeability (log P is -2.9). The current investigation's objective is the development of solid lipid microparticles-based sustained topical release delivery with enhanced permeability of eflornithine hydrochloride. EFH-loaded solid lipid microparticles (EFH-SLM) composed of Monecol PC and Softemul 165 using emulsion solvent evaporation technique.
URI:	https://doi.org/10.33263/BRIAC121.618637 http://hdl.handle.net/123456789/2638
Appears in Collections:	Journals

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