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Title: Deciphering the molecular role of non-coding RNA in malignant cardiac disease
Authors: Sharma I
Behl T
Sehgal A
Sachdeva M
Singh S
Sharma N
Bungau S
Keywords: Non-coding RNA
myocardial infarction
heart failure
Issue Date: 2021
Publisher: Biointerface Research in Applied Chemistry
Abstract: Non-coding RNA (NcRNA) is a functional RNA which contributes to the gene regulation at both transcriptional and post-transcriptional level. NcRNA lack in the encoding of proteins, but this does not counteract the generic functioning of the cells. It is a group of RNA with versatile functioning. They are classified into small nuclear RNA, tRNA, rRNA, and microRNA. The cumulative functioning of ncRNA includes slicing as well as the management of chromosomes. The long ncRNA plays a vital role in malignant cardiovascular disease such as atherosclerosis, myocardial infarction, and injury. They act by different pathways and undergo different mechanisms that include binding to CBX, activating mesoderm posterior-1, modulating MKX25, and targeting bone morphogenetic proteins. They have an intricate role in cardiovascular disorders as some of the long ncRNAs contribute to the inhibition of plague formation in the heart, thus reducing the risk for atherosclerosis and thus retarding the development of heart failure. Whereby microRNA acts as a prognostic biomarker in the early detection of heart injury. MicroRNA has even been identified for the inhibition of angiogenesis, and Piwiinteracting RNA is important in genetic diversity. Thus, ncRNA is one of the factors in the leading cause of malignant cardiac disorder and is responsible for cardiac remodelling andheart failure.
URI: 10.33263/BRIAC114.1174711764
Appears in Collections:Journals

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