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Title: Exploring the focal role of pyroptosis in diabetes mellitus
Authors: Sharma I
Behl T
Sehgal A
Singh S
Sharma N
Singh H
Hafeez A
Bungau S
Keywords: pyroptosis
diabetes mellitus
Issue Date: 2021
Publisher: Biointerface Research in Applied Chemistry
Abstract: Diabetes mellitus is a T cell-mediated disease associated with the depletion of beta cells responsible for insulin production. Although the disease is T cell-mediated, it undergoes various biochemical responses and programmed cell death. Programmed cell death, a distinct biochemical pathway in which cells die by eliciting various physiological outcomes. Pyroptosis, apoptosis, and necrosis are the three major forms of programmed cell death that function as a defense mechanism against various infections, diseases, and microorganisms. This review article focuses on the various pathological mechanisms of pyroptosis. Pyroptosis is distinguished by the caspase-1-dependent formation of plasma membrane pores, resulting in the release of pro-inflammatory cytokines, leading to cell lysis. Caspase-1, a protease which is an interleukin-1L-1? converting enzyme that initiates the cell death process by converting interleukin-1L-1? into mature inflammatory cytokine (mature form). Emerging evidence has made pyroptosis a vital trigger as well as an endogenic regulator of diabetes mellitus.
URI: 10.33263/BRIAC115.1355713572
Appears in Collections:Journals

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