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Title: Elucidating the role of heat shock protein in diabetic retinopathy
Authors: Sheetu Behl T
Singh S
Sharma N
Sehgal A
Sharma S
Hafeez A
Bungau S
Keywords: Heat shock proteins
diabetic retinopathy
molecular chaperons
small heat shock proteins (sHSPs).
Issue Date: 2021
Publisher: Biointerface Research in Applied Chemistry
Abstract: The rising world-wide health and the economic burden were caused by diabetes and associated complications. Cataract genesis and retinopathy are eye-catching forms of diabetes, which are the most important cause of blindness in the workforce. Notwithstanding various research and recent advances, it is still important to thoroughly elucidate the disease's exact pathophysiology and establish new and effective treatment methods for this chronic disorder. Highly preserved protein families (HSPs) act as defensive moles, which play a wide range of functions and can be manifested in response to various cell stresses. Numerous recent studies have demonstrated their presence in multiple eye conditions [1], including diabetic retinopathy. Earlier identification and timely treatment of visual DR has reduced visual loss incidence and development. To develop new successful preventative strategies in the early stages of DR, a multidisciplinary approach is needed. Moreover, clinical trials have shown correlations between diabetic complications and altered HSP and anti-HSP circulating levels. This makes HSP a therapeutic opportunity that is exciting and could be useful as a clinical biomarker. However, this research area is still very young, and further studies are needed both in the field of experimental diabetes and in humans to gain a complete understanding of HSP relevance.
URI: 10.33263/BRIAC116.1419614224
Appears in Collections:Journals

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