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Title: Recent updates on free fatty acid receptor 1 (Gpr-40) agonists for the treatment of type 2 diabetes mellitus
Authors: Rani L
Grewal A S
Sharma N
Singh S
Keywords: Antidiabetic
FFAR1 agonist
free fatty acid receptor
type 2 diabetes mellitus.
Issue Date: 2021
Publisher: Mini-Reviews in Medicinal Chemistry
Abstract: The global incidence of type 2 diabetes mellitus (T2DM) has enthused the development of new antidiabetic targets with low toxicity and long-term stability. In this respect, free fatty acid receptor 1 (FFAR1), which is also recognized as a G protein-coupled receptor 40 (GPR40), is a novel target for the treatment of T2DM. FFAR1/GPR40 has a high level of expression in ?-cells of the pancreas, and the requirement of glucose for stimulating insulin release results in immense stimulation to utilise this target in the medication of T2DM.
URI: 10.2174/1389557520666201023141326
Appears in Collections:Journals

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