Review article management of rheumatoid arthritis : A nanomedicine perspective

Abstract

Rheumatoid arthritis (RA), a chronic and joint-related autoimmune disorder, leads to immune dysfunction and destruction of joints and cartilages. Little molecules and biological therapies are applied in a very wide variety of inflammatory disorders; however, their utility as a therapeutic agent is proscribed by poor absorption, speedy metabolism, and serious side effects. To improve these limitations, nanomedicines, that are capable of encapsulating and protective medicine from degradation before they reach the target site in vivo, could serve as drug delivery systems. The current studies demonstrated that the efficacy gets improved when a drug is administered in a nanoparticle formulation as compared to the free drug, mainly in three aspects: Selective accumulation, controlled drug release, and reduced systemic toxicity. The newly developed nanocarriers significantly enhance the therapeutic effectiveness of current drugs to treat RA in experimental models by overall dose reduction and higher local drug localization by passive and active drug targeting. Therefore, in this review we explore newly discovered nanomedicines and their role in rheumatoid arthritis. � 2020 Plant Archives. All rights reserved.