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Title: Review article chalcones: A privileged scaffold with diverse biological activities
Authors: Singh M
Sharma P
Joshi P
Saini K
Sharma A
Puri V
Chander J
Singh T.G
Arora S.
Keywords: Anti-Cancer
Issue Date: 2020
Publisher: Plant Archives
Abstract: This review article provides information on the biological activities of chalcone whether natural or synthetics derivatives. Chalcone (1,3-diaryl-2-propen-1-ones) derivatives are widely found naturally (pteridophytes to multicellular organism). Chemically it consist of open-chain flavonoids in which the two aromatic rings are joined by a three-carbon -unsaturated carbonyl system. Chalcones have been reported to possess many pharmacological activities, including anti-inflammatory, antimicrobial, antifungal, antiviral antioxidant, hepato-protective, anti-cancer activities and also have been reported to manage cardiovascular system disorders. Chalcones are secondary metabolites found in plants. Some natural flavonoids also help in hostility oxidative stress and play vital role as growth regulators, chalcones may exist in cis or trans form and trans form is more favorable. Some chalcones are isolated naturally from different plants, and have been approved for clinical trials in the treatment of cancer, cardiovascular disorders, viral diseases and have extensively shown one or more pharmacological activities. The main objective of this review article is that to summarize the recent development in the pharmacological or biological activities of natural or synthetic chalcone. � 2020 Plant Archives. All rights reserved.
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