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|Title:||Central composite designed solid dispersion for dissolution enhancement of fluvastatin sodium by kneading technique|
|Keywords:||central composite design|
polyethylene glycol 6000
polyvinyl pyrollidone K-30.
|Publisher:||Future Medicine Ltd.|
|Abstract:||Aim: This research is focused on enhancing aqueous solubility and dissolution of fluvastatin sodium (FSS) through solid dispersion (FSS-SD) production using polyethylene glycol 6000 and polyvinyl pyrollidone K-30 by kneading technique. Methodology & results: Central composite design explored the influence of polyethylene glycol 6000 and polyvinyl pyrollidone K-30 on T50% and Q90. The aqueous saturation solubility of FSS (8.7 � 1.12 ?g/ml) was amplified 20-fold in FSS-SD (179 � 4.16 ?g/ml). Cumulative drug release from FSS and optimized FSS-SD were 27.49 and 87.4% within 90 min, respectively. Conclusion: FSS-SD production using kneading technique offers great prospective in maximizing FSS's solubility and dissolution.|
|Appears in Collections:||Journals|
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