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Title: Early diagnosis of pancreatic cancer: The key for survival
Authors: Gheorghe G
Bungau S
Ilie M
Behl T
Vesa C.M
Brisc C
Bacalbasa N
Turi V
Costache R.S
Diaconu C.C.
Keywords: Biomarkers
carbohydrate antigen 19-9 (CA19.9)
early diagnosis
pancreatic cancer
risk factors.
Issue Date: 2020
Publisher: MDPI AG
Abstract: Pancreatic cancer (PC) is one of the most aggressive forms of cancer. Negative prognosis is mainly due to the late diagnosis in advanced stages, when the disease is already therapeutically overcome. Studies in recent years have focused on identifying biomarkers that could play a role in early diagnosis, leading to the improvement of morbidity and mortality. Currently, the only biomarker widely used in the diagnosis of PC is carbohydrate antigen 19-9 (CA19.9), which has, however, more of a prognostic role in the follow-up of postoperative recurrence than a diagnostic role. Other biomarkers, recently identified as the methylation status of ADAMTS1 (A disintegrin and metalloproteinase with thrombospondin motifs 1) and BNC1 (zinc finger protein basonuclin-1) in cell-free deoxyribonucleic acid (DNA), may play a role in the early detection of PC. This review focuses on the diagnosis of PC in its early stages.
URI: 10.3390/diagnostics10110869
Appears in Collections:Journals

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