Insight into the role of inflammation in progression of diabetes associated neuropathy

Abstract

Diabetes is major fatal disease that gives the outbreak to the vast mortality rate in India. Most of the diabetic patients affected by foot ulcers and deposition of lesions in foot, arms, hands, and legs due to inflammation caused by means of various physical and chemical extremities contributing in the etiology of inflammatory diabetic neuropathy. In various neuropathic pains the most common is diabetic peripheral neuropathy (DPN) which affect leg region. It is characterized by the small and large nerve fibers autonomic alterations. The symptoms of DPN is basically occurs above the 50 years of age group. Inflammation, oxidative stress and mitochondrial dysfunction are the three main alterations involved in diabetic neuropathy. Inflammation persuades the stimulation of activator protein-1, nuclear factor kappa b (NF-Kb), and protein kinases stimulated by mitogen. Prolonged neuropathic damage in peripheral region will not be recovered, but there are many recent researches came out by which the progression of the lesion can be controlled by some effective measures. Many effective non-steroidal anti-inflammatory drugs have the potent actions on the peripheral pain in inflammatory diabetic neuropathy as well as multifocal sites in the polyneuropathy. Due to many complications occur in diabetes mellitus certain sites are prone to spread the inflammatory lesions, resulting in many difficult problems which can be treated as per the progression of the disease. Many patients were treated by the certain combinations of medication like prednisone and other non-steroidal anti-inflammatory diseases (NSAIDs), or can be diagnosed by the plasmapheresis and intravenous immune globulins.