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Title: Nefopam hydrochloride loaded microspheres for post-operative pain management: synthesis, physicochemical characterization and in-vivo evaluation
Authors: Sharma N
Arora S
Madan J.
Keywords: anti-nociceptive
mechanical allodynia
Issue Date: 2018
Publisher: Taylor and Francis Ltd.
Abstract: Once-daily oral dosage of nefopam hydrochloride loaded sustained release microspheres (NPH-MS) was investigated as novel therapeutic strategy for post-operative pain management. Microspheres were synthesized using poly-3-hydroxybutyrate and poly-(?-caprolactone) by double emulsion solvent evaporation technique. NPH-MS were characterized through FTIR, PXRD and SEM. In-vitro drug release study revealed sustained behavior till 24 h. Haemolysis was <5% which signified haemocompatibility of formulation. ED50 in rat tail-flick anti-nociceptive test was found ?18.12 mg/kg. In post-operative pain model, reversal of mechanical allodynia and thermal hyperalgesia by NPH-MS was statistically significant (p <.001) as compared with NPH till 24 h post-dose. � 2017 Informa UK Limited, trading as Taylor & Francis Group.
URI: 10.1080/21691401.2017.1301459
Appears in Collections:Journals

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