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Title: Formulation, Optimization and Evaluation of Sustained Release Microspheres using Taguchi Design
Authors: Sukhbir Singh
Keywords: Taguchi
Response Variables
Independent Variables
Drug Entrapment Efficiency
Drug Loading
Higuchi Model
Issue Date: 30-May-2014
Publisher: Chitkara University Publications
Abstract: The aim of present study is to prepare microspheres of eudragit RL 100 loaded with Nefopam Hydrochloride by single emulsion solvent evaporation technique. Taguchi L9 orthogonal array design has been used to optimize the composition and operating conditions for preparation of formulations. Nine batches (F1-F9) were prepared by taking three independent variables (X1- drug: polymer ratio, X2- stirring speed and X3- stirring time) at three levels (+1, 0, -1). Response variables studied for batches (F1-F9) were mean particle size (μm) (Y1), drug entrapment efficiency (% w/w) (Y2) and drug loading (% w/w) (Y3). Drug- polymer compatibility study was carried out by DSC and FTIR spectroscopy and indicates no physicochemical interaction. Microspheres were analyzed for morphological characteristics, mean particle size, drug entrapment efficiency, drug loading and in-vitro drug release. Percentage cumulative drug release for optimized batch F5 was found to be 85.421 ± 0.054 and followed higuchi model for release of drug.
ISSN: Print 2321-2217
Online 2321-2225
Appears in Collections:JPTRM Volume 2 Number 1 (May - 2014)

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