Formulation And Characterization of Carageenan Gels Encapsulating Amphotericin B And Lactobacillus acidophilus Against Candidal Vaginitis

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dc.contributor.authorR. Kaur
dc.contributor.authorM. Khurana
dc.contributor.authorM. Bindal
dc.contributor.authorA. Sharma
dc.date.accessioned2025-12-06T04:49:19Z
dc.date.available2025-12-06T04:49:19Z
dc.date.issued2017-10-02
dc.description.abstractThe present study is concerned with the development and characterization of bioadhesive carageenan gel encapsulating Amphotericin B and Lactobacillus acidophillus, prepared by graft co-polymeriztion against Candidal vaginitis. Intravaginal gel systems based on bioadhesive polymer (carrageenan) were characterized with respect to swelling index, bioadhesive strength, percent encapsulation and in vitro drug release antimicrobial studies. A marked increase in swelling index of gel encapsulating Lactobacillus was found to be 1.9±0.35. The percent encapsulation of drug was found to be 98.63%±.0.2% and that of Lactobacillus was 91.81 ±0.01. The viability was observed for interval of 6 hrs on trypton soya agar and showed that viability was highly conserved till 4 hrs. The antimicrobial study of gels encapsulating Amphotericin B and Lactobacillus showed that carageenan gel can inhibit Candida albicans upto a maximum extent. Bioadhesivity study also conducted for gels that showed a bioadhesivity of 84.66% ±.0.5% with drug, 88.66% ±.02% with Lactobacillus. In-vitro drug release showed a sustained type release of drug from the polymer i.e. there was initial burst of Amphotericin B up to 5 hours, after which there was a sustained release upto 10 days. Thus it has been concluded from the present study that bioadhesive gels encapsulating Amphotericin B can act as promising drug carriers along with Lactobacillus against candidal vaginitis.
dc.identifier.issn2393-8536
dc.identifier.issn2393-8544
dc.identifier.otherhttps://doi.org/10.15415/jmrh.2017.41004
dc.identifier.urihttps://demodspace.chitkara.edu.in/handle/123456789/92
dc.language.isoen
dc.publisherChitkara University Publications
dc.subjectCandidal Vaginitis
dc.subjectCarageenan
dc.subjectSwelling index
dc.subjectEncapsulation
dc.subjectBioadhesivity
dc.titleFormulation And Characterization of Carageenan Gels Encapsulating Amphotericin B And Lactobacillus acidophilus Against Candidal Vaginitis
dc.typeArticle

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JMRH Vol. 4 No. 1 (October 2017)