Clinicopathological Correlation of Prostatic Lesions with Serum PSA Levels: An Observational Analysis

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dc.contributor.authorPooja Khandwe
dc.contributor.authorSheela Chikhalikar
dc.contributor.authorDimple Kalsi
dc.contributor.authorArchana Patil
dc.date.accessioned2026-07-23T04:53:23Z
dc.date.available2026-07-23T04:53:23Z
dc.date.issued2025-11-11
dc.description.abstractBackground: Prostatic diseases, including benign prostatic hyperplasia (BPH), prostatitis, and carcinoma, are common in elderly males and contribute significantly to morbidity. Serum prostate-specific antigen (PSA) is widely used as a diagnostic and monitoring tool, though its specificity for malignancy is limited. Purpose: To evaluate the clinicopathological correlation of various prostatic lesions with serum PSA levels and age distribution. Methods: This observational study was conducted in the Department of Pathology at a tertiary care center in Nashik from August 2019 to December 2021. A total of 110 prostatic specimens, including TURP chips, needle biopsies, and open prostatectomy specimens, were analyzed. Histopathological examination, Gleason grading, and serum PSA measurement were performed. Data were analyzed using EpiInfo 7.2, with p < 0.05 considered statistically significant. Results: Among 110 specimens, TURP was most frequent (68.18%), followed by needle biopsy (26.36%) and open prostatectomy (5.45%). BPH was the predominant lesion (76.36%), while carcinoma accounted for 17.27% of cases. The 61–70-year age group had the highest incidence of both benign and malignant lesions (46.36%). Mean serum PSA was significantly higher in malignant lesions (89.82 ± 52.32 ng/ml) and atypical small acinar proliferation (54.93 ± 65.08 ng/ml) compared to BPH and PIN (7.56 ± 12.38 ng/ml). Gleason scores 7 and 8 were most frequent among carcinoma cases (31.57% and 31.57%, respectively). Conclusion: BPH is the most common prostatic lesion in elderly males, while PSA levels correlate strongly with malignancy and atypical lesions. Histopathological evaluation and Gleason scoring remain essential for diagnosis and management.
dc.identifier.issn2393-8536
dc.identifier.issn2393-8544
dc.identifier.otherhttps://doi.org/10.15415/jmrh.2025.112008
dc.identifier.urihttps://demodspace.chitkara.edu.in/handle/123456789/671
dc.language.isoen
dc.publisherChitkara University Publications
dc.subjectProstate
dc.subjectBenign prostatic hyperplasia
dc.subjectProstate carcinoma
dc.subjectPSA
dc.subjectGleason score
dc.titleClinicopathological Correlation of Prostatic Lesions with Serum PSA Levels: An Observational Analysis
dc.typeArticle

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JMRH Vol. 11 No. 2 (June 2025)