Browsing by Author "Rupinder Kaur"

Now showing 1 - 2 of 2
  • No Thumbnail Available
    Item
    Diabetic Retinopathy: An Insight into Clinical Features, Therapeutic Approaches, and Implications
    (Chitkara University Publications, 2021-05-07) Rupinder Kaur; Rithik; Kirti; Suman Baishnab; Shareen Singh
    Background: Diabetes mellitus is a metabolic disorder that affects the heart, brain, eye, and other organs. Diabetic microvascular complications includes retinopathy, nephropathy, and neuropathy. Diabetic retinopathy is a multifactorial disease that develops as a consequence of microvascularcom plications, which causes damage to the retina by damaging the ocular fundus which further leads to visual loss. Purpose: Pharmacological and non-pharmacological treatment works to prevent, delay or reduce vision loss. Non-pharmacological treatment include nutraceuticals (they have anti-inflammatory and antioxidant property) and pharmacological treatment includes anti-VEGF agents, corticosteroids, and specific moieties. Treatment with nutraceuticals in the early stages of diabetic retinopathy could be a viable option for intervening before the disease progresses. Conclusion: This review briefly elucidates the emerging condition of diabetic retinopathy from epidemiological, pathophysiological, and therapeutic aspects including the emerging uses of nutraceuticals in diabetic retinopathy. If we control glucose and blood pressure levels in diabetic patients, it may halt the progression and development of diabetic retinopathy.
  • No Thumbnail Available
    Item
    Therapeutic Applications And Risks of Papaver Somniferum L. Alkaloids In Cancer Pain And Acute Cardiogenic Pulmonary Oedema
    (Chitkara University Publications, 2025-08-25) Karan Thakur; Shivam Thakur; Abhay Sharma; Khemender Lidoo; Om Kumar; Scindia Kohli; Rupinder Kaur; Amit Sharma; Sarita Jangra
    Background: Papaver somniferum L. (opium poppy) is a historically significant medicinal plant, primarily known for its potent alkaloids such as morphine, codeine, and thebaine. With the global rise in opioid use and misuse, understanding the medical potential and risks of poppy-derived compounds has gained renewed significance, particularly in contexts such as cancer-related pain and acute cardiogenic pulmonary edema (ACPE). Purpose: This review evaluates the efficacy and pharmacological mechanisms of P. somniferum alkaloids, particularly morphine, in managing cancer-related pain and acute cardiogenic pulmonary edema (ACPE), alongside associated risks and regulatory concerns. Method: A literature review was conducted, synthesizing data from peer-reviewed studies sourced from PubMed, Google Scholar, Scopus, and Web of Science, focusing on pharmacological, clinical, and biochemical properties of poppy alkaloids. Results: Morphine effectively controls severe cancer pain (80–90% pain reduction in clinical trials) via mu-opioid receptor modulation but is underutilized due to addiction concerns. In ACPE, morphine reduces preload and anxiety but lacks clear survival benefits, with risks like respiratory depression (10–15% incidence) and drug interactions. Conclusion: While Papaver somniferum-derived morphine remains a cornerstone in palliative pain management, its use in ACPE should be approached cautiously due to unclear survival benefits and notable risks.