Browsing by Author "Himanshu Sharma"

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    Allium Sativum-Boon to the Herbal World
    (Chitkara University Publications, 2024-04-20) Sanchit Dhankhar; Himanshu Sharma; Samrat Chauhan; Pooja Mittal; Vishnu Mittal
    Background: For many years, people have utilized Allium Sativum as a spice, culinary addition, and natural cure for several common illnesses, such as earaches, burns, wounds, baldness, migraines, chest colds, dog bites, and insect stings. It is believed that minerals, protein, fixed oil, thiamine, ascorbic acid, and allin are responsible for the therapeutic benefits of Allium Sativum. Purpose: This review covers the pharmacology, pharmacognosy, pharma chemistry, and other therapeutic aspects of this plant. Aside from its antibacterial, antioxidant, and anticancer qualities, allicin is a helpful treatment for cardiovascular disorders. To lessen reactive oxygen species (ROS), the antioxidant allicin inhibits the enzymes that oxidise NADPH. By engaging with various peroxidases, it can also directly lower the concentrations of various ROS within cells. As an inhibitor of cholinesterase, butyrylcholinesterase (BuChE), and autism spectrum disorder (ASD), it treats these disorders. Furthermore, it aids in the preservation of neurotransmitter balance in individuals with ADHD and attention deficit hyperactivity disorder. Methods: Recent literature has been surveyed from PUBMED, Google Scholar, etc. like search engines, for summarizing detailed on-going on the phytochemical properties, biological activities, marketed formulations, patents and therapeutic potential of Allium Sativum (garlic). The search strategy included keywords such as “Allium Sativum,” “allicin,” “garlic therapeutic properties,” “neuroinflammation,” “antioxidant activity,” “phytochemicals,” “marketed formulations, ” “patents, ” and “drug delivery systems.” Results: Allium Sativum offers broad therapeutic benefits, including antibacterial, antioxidant, and cardiovascular protection, making it a valuable natural remedy for various health conditions. Conclusion: Allicin therapy can lessen the effects of metal-induced neurotoxicity in addition to enhancing cognitive function in neurologically ill individuals. Moreover, it may pass across cell membranes with ease. This molecule can oxidise the links that keep cysteine residues in proteins together and the thiol groups in glutathione. It is physiologically active. Aside from its antibacterial, antioxidant, and anticancer qualities, allicin is a helpful treatment for cardiovascular disorders. To lessen reactive oxygen species (ROS), the antioxidant allicin inhibits the enzymes that oxidize NADPH. By engaging with various peroxidases, it can also directly lower the concentrations of various ROS within cells. As an inhibitor of cholinesterase, butyrylcholinesterase (BuChE), and autism spectrum disorder (ASD), it treats these disorders.
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    Hydrogels in Chronic Wound Care: A Multifaceted Approach to Healing and Regeneration
    (Chitkara University Publications, 2025-08-25) Himanshu Sharma; Sanchit Dhankhar; Vishnu Mittal; Balraj Saini; Pooja Mittal; Akashdeep Singh
    Background: In wealthy nations, 1-2% of people suffer from serious chronic wounds. In India, chronic wounds have a prevalence rate of approximately 4.5 per 1000 individuals, with diabetic foot ulcers and pressure ulcers being the most common. Purpose: Chronic wound treatment is necessary to maintain patients’ physical and emotional well-being and improve quality of life. Numerous methods, including hydrogel dressings, skin grafts, debridement, ultrasound, electromagnetic, and negative pressure wound treatment, may be used to treat chronic wounds. Methods: Recent literature has been surveyed from PUBMED, GOOGLE SCHOLAR, etc., like search engines, for summarizing detailed ongoing developments in the field of hydrogels in chronic wound care. Conclusions: Due to their functional qualities that may be adjusted, hydrogel dressings are a viable and promising solution for accelerating the healing of chronic wounds. These characteristics include biodegradability, adhesion, and bioactivities that are pre-antigenic, antibacterial, and anti-inflammatory. This overview summarizes the various types of chronic wounds, stages of the healing process, and important treatment modalities. The advantages of hydrogel-based dressings for treating chronic wounds are discussed, along with their multifunctional qualities, illustrating their superiority over other dressing types for long-term wound healing.