Browsing by Author "Balraj Saini"

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    Hydrogels in Chronic Wound Care: A Multifaceted Approach to Healing and Regeneration
    (Chitkara University Publications, 2025-08-25) Himanshu Sharma; Sanchit Dhankhar; Vishnu Mittal; Balraj Saini; Pooja Mittal; Akashdeep Singh
    Background: In wealthy nations, 1-2% of people suffer from serious chronic wounds. In India, chronic wounds have a prevalence rate of approximately 4.5 per 1000 individuals, with diabetic foot ulcers and pressure ulcers being the most common. Purpose: Chronic wound treatment is necessary to maintain patients’ physical and emotional well-being and improve quality of life. Numerous methods, including hydrogel dressings, skin grafts, debridement, ultrasound, electromagnetic, and negative pressure wound treatment, may be used to treat chronic wounds. Methods: Recent literature has been surveyed from PUBMED, GOOGLE SCHOLAR, etc., like search engines, for summarizing detailed ongoing developments in the field of hydrogels in chronic wound care. Conclusions: Due to their functional qualities that may be adjusted, hydrogel dressings are a viable and promising solution for accelerating the healing of chronic wounds. These characteristics include biodegradability, adhesion, and bioactivities that are pre-antigenic, antibacterial, and anti-inflammatory. This overview summarizes the various types of chronic wounds, stages of the healing process, and important treatment modalities. The advantages of hydrogel-based dressings for treating chronic wounds are discussed, along with their multifunctional qualities, illustrating their superiority over other dressing types for long-term wound healing.
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    Standardization of Some Commercial Anti-diabetic Herbal Products containing Syzygiumcumini
    (Chitkara University Publications, 2017-05-05) Jasmeen Kaur; Munish Singla; Balraj Saini; Gulshan Bansal
    An isocratic HPLC method was developed for standardization of five commercially available products containing S. cumini seeds (DIABECON, MADHULENE, HYPONIDD, D-FIT and DIABEGON)using methylxanthoxylin (MXX)as marker. The method was validated in accordance with ICH Q2(R1) guidelines. The chromatographic separation of MXX was achieved on a C18 column by mobile phase composed of methanol and water (60:40%v/v) at a flow rate 0.5 mL/min. The eluent was detected at 280 nm. The method was linear over concentration of 1-200 μg/mL with correlation coefficient of 0.9999. The LOD and LOQ were 0.175 and 0.530 µg/mL, respectively. The method was precise (%RSD <0.31), accurate and robust for determination of MXX in herbal extracts. The content of MXX in the seed extract was found to be 0.0433%w/w while it was ranging from 0.026- 0.041%w/w in the products. The content of MXX was found to be equivalent to the pure seed extract only in DIABECON tablets and D-FIT soft gelatine capsules while it was found to be significantly less in the other formulations.
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    WHO Guided Real Time Stability Testing on Shankhpushpi Syrup
    (Chitkara University Publications, 2017-05-05) Astha Jain; Jasmeen Kaur; Nancy; Yogita Bansal; Balraj Saini; Gulshan Bansal
    Shankhpushpiis widely used herb in numerous CNS active Ayurvedic formulations, which are consumed by population of all age groups. The present study is designed to evaluate the stability of commercially available shankhpushpi syrup as per WHO guidelines. The study was conducted under long term conditions for 12 months on three different batches of the product. An HPLC-UV method was developed and validated to determine the marker (scopoletin) content in the stability samples. Peak purity was determined using HPLC-PDA analysis. Each stability sample was investigated for any change in physical, chemical and biological parameters with respect to control sample. The product was found to be stable in terms of physical parameters whereas significant change was observed in total phenolic content and content of scopoletin. The antioxidant, acetylcholine esterase inhibitory and antianxiety activities of the stability samples decreased with respect to control sample. Moreover, there was significant variation in chemical and biological parameters among the batches. The findings suggested that the product was unstable and further studies are required to be conducted in order to determine the shelf life of the product.