Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/671
Title: Histone Deacetylase Inhibitors As Potential Therapeutic Agents For Various Disorders
Authors: THAPA, KAJAL
KUMAR, SAVIR
SHARMA, ANURAG
ARORA, SANDEEP
GREWAL, AMARJOT KAUR
SINGH, THAKUR GURJEET
Keywords: Epigenetic
Histone
Acetylation
Deacetylation
Lysine
Histone deacetylases inhibitors
Issue Date: 2-Nov-2017
Publisher: Chitkara University Publications
Abstract: Epigenetic modification acetylation or deacetylation of histone considered as an important element in various disorders. Histone acetyltransferases (HATs) and histone deacetylases (HDACs) are the enzymes which catalyse the acetylation and deacetylation of histone respectively. It helps in regulating the condensation of chromatin and transcription of genes. Lysine acetylation and deacetylation present on the nucleosomal array of histone is the key factor for gene expression and regulation in a normal working living cell. Modification in histone protein will lead to the development of cancer and can cause various neurodegenerative disorders. To safeguard the cells or histone proteins from these diseases histone deacetylase inhibitors are used. In this review, the main focus is upon the role of histone deacetylases inhibitors in various diseases.
URI: http://hdl.handle.net/123456789/671
ISSN: Print 2321-2217
Online 2321-2225
Appears in Collections:JPTRM Volume 5 Number 2 (November - 2017)

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