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|Title:||A Review on Role of Advanced Glycation End products (AGEs) in Rheumatoid Arthritis|
|Keywords:||Advance glycated end products|
|Publisher:||Chitkara University Publications|
|Abstract:||Rheumatoid arthritis (RA) is a systemic inflammatory connective tissue disease with polyarthritis as a prominent feature; however, extra-articular symptoms and signs are always present. Advanced glycation end products with ability of cross-linking of proteins characteristic fluorescence and reaction with AGE-specific receptor RAGE (receptor for AGEs). AGEs action as well as AGE formation is directly related to both to inflammation and oxidative stress. RAGE is a 35-kDa polypeptide whose gene is located at the junction of the class II and III HLA regions on chromosome. AGE ligation of RAGE has been shown to activate p21ras and mitogen-activated protein (MAP) kinase, and stimulate nuclear translocation of the transcription factor NF-κB, thereby, resulting in the transcription of target genes thus may induce chronic cellular activation and tissue damage.|
|Appears in Collections:||JPTRM Volume 3 Number 1 (May - 2015)|
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